Oligodeoxynucleotides containing 5-alkyl, 5-(1-alkenyl)- and 5-(

Details Oligodeoxynucleotides containing 5-alkyl, 5-(1-alkenyl)- and 5-( Oligodeoxynucleotides containing 5-alkyl, 5-(1-alkenyl)- and 5-(

1997-09-22

1998-06-16

Elliott, George C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 241, C07H 2100, C07H 2104

Patent

active

057672644

ABSTRACT:
A 12 to 30 nucleotide-unit long oligonucleotide that comprises at least one 5-substituted uracil or cytosine, where the 5-substituent is a C.sub.3-6 n-alkyl, a vinyl, a butenyl, an ethynyl, or a C.sub.4-12 n-1-alkynyl, with the proviso that the uracil moiety may not be substituted with an n-alkyl or a C.sub.8-12 n-1-alkynyl.

REFERENCES:
patent: 5484908 (1996-01-01), Froehler et al.
Kim, S. "The Influence of oligodeoxyribonucleotide phosphorothioate pyrimidine strands on triplex tormation," FEBS vol. 314 (1) pp. 29-32 Dec. 1992.
Xodo, et al "Effect of 5-metlylcytosine on the stability of triple stranded DNA -a thermodynamic study," NAR vol. 19(20) 1991 pp. 5625-5631.
Froeitzer et al "0ligodeoxynucleotides containing C-5 Propyne Analogs of 2'-Deoxyuridine and 2' Deoxycytidine," Tetrahedron Letters. vol. 33(37) pp. 5307-5310 1992.

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