Soluble prodrugs of paclitaxel

Details Soluble prodrugs of paclitaxel Soluble prodrugs of paclitaxel

1997-06-03

2000-11-28

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549510, 549511, C07D40502, C07D30514

Patent

active

06153756&

ABSTRACT:
Novel 2'-onium salts of paclitaxel act as prodrugs in mammalian patients to yield paclitaxel in vivo. Methods of synthesizing these onium salts are disclosed, as are methods of treating patients suffering from paclitaxel-responsive diseases by administering effective amounts of the onium salts and pharmaceutical compositions containing the novel salts which are suitable for administration to patients requiring paclitaxel therapy.

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