Modified ether glyceroglycolipids

Details Modified ether glyceroglycolipids Modified ether glyceroglycolipids

1996-09-26

2000-11-28

Lee, Howard C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 25, 514 62, 536 552, 536120, 568673, 568678, C07H 1506, C07H 506, A61K 3170

Patent

active

061537365

ABSTRACT:
This invention provides lipids having: 1) a glycerol backbone; 2) a hydrocarbon chain, preferably saturated and containing 16 or 18 carbon atoms, attached to C-1 of the backbone by an ether linkage; 3) a methyl group attached to C-2 of the backbone, preferably by an ether linkage; and, 4) a sugar attached to C-3 of the glycerol backbone in either the alpha or beta anomeric configuration, the sugar being altered by modification of, or substitution for, one or more of its hydroxyl groups. Also provided herein are ether-lipid-containing compositions, as well as methods of administering such compositions to animals, for example, those afflicted with cancers, as well as various other diseases and disorders.

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Bittman et al., "Glycosylated Antitumor Ether Lipids: Synthesis and Growth-Inhibitory Properties", Abstract Book XIXth International Carbvohydrate Symposium, University of California, San Diego, USA, Aug. 9-14, 1998.
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