Prodrug forms of ribonucleotide reductase inhibitors 3-AP and 3-

Details Prodrug forms of ribonucleotide reductase inhibitors 3-AP and 3- Prodrug forms of ribonucleotide reductase inhibitors 3-AP and 3-

1997-05-15

1998-06-16

Davis, Zinna Northington

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546306, A61K 3144, C07D21302

Patent

active

057671346

ABSTRACT:
The present invention relates to novel prodrug forms of ribonucleoside diphosphate reductase inhibitors 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) 3-amino-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-AMP) which have increased water solubility, bioavailablity and resistance to in vivo acetylation of their amino functions. Novel compounds according to the present invention relate to those of the formula: ##STR1## where R.sup.4 is H or CH.sub.3 and

REFERENCES:
patent: 4385055 (1983-05-01), Klayman et al.
patent: 4447427 (1984-05-01), Klayman et al.
patent: 4696938 (1987-09-01), Le

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