Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrim

Details Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrim Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrim

1992-06-22

1993-08-10

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544229, C07D48704, C07B 3900, C07F 718

Patent

active

052350533

ABSTRACT:
4-Hydroxypyrrolo[2,3-d]pyrimidines are regiospecifically halogenated at the C-5 position by silylation in the presence of an inert organic solvent and iodination, bromination or chlorination.

REFERENCES:
patent: 4996206 (1991-02-01), Taylor et al.
Seela, Chem. Ber 111, 2925 (1978).
Cocuzza, A. J., Tetrahedron Letters, 29:4061-4064 (1988).
Gerster, et al., J. Het. Chem., 6:207-213 (1969).
Noell, et al., J. Het. Chem., 1:34-41 (1964).

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