Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-12-23
2000-11-28
Schwartzman, Robert A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530324, 530350, 530399, A61K 3818, C07K 1451
Patent
active
061535834
ABSTRACT:
Disclosed are (1) nucleic acid and amino acid sequences for a novel morphogenic protein; (2) methods for producing and expressing the protein in a biologically active form; and (3) methods for utilizing the protein to induce tissue morphogenesis in a mammal, including methods for increasing a progenitor cell population in a mammal, methods for stimulating progenitor cells to differentiate and maintain their differentiated phenotype in vivo or in vitro, methods for inducing tissue-specific growth in vivo and methods for the replacement of diseased or damaged tissue in vivo.
REFERENCES:
patent: 4877864 (1989-10-01), Wang et al.
patent: 4968590 (1990-11-01), Kuberasampath et al.
patent: 4975526 (1990-12-01), Kuberasampath et al.
patent: 5002965 (1991-03-01), Ramwell et al.
patent: 5011691 (1991-04-01), Oppermann et al.
patent: 5013649 (1991-05-01), Wang et al.
patent: 5091513 (1992-02-01), Huston et al.
patent: 5106626 (1992-04-01), Parsons et al.
patent: 5108753 (1992-04-01), Kuberasampath et al.
patent: 5141905 (1992-08-01), Rosen et al.
Wong et al. (1975), "Target Cells In Bone For Parathormone And Calcitonin Are Different: Enrichment For Each Cell Type By Sequential Digestion Of Mouse Calvaria And Selective Adhesion To Polymeric Surfaces," 72 Proc. Natl. Acad. Sci. USA 3167-3171.
Sampath et al. (1983), "Homology Of Bone-Inductive Proteins From Human, Monkey, Bovine, And Rat Exttacellular Matrix," 80 Proc. Natl. Acad. Sci. 6591-6595.
Mason et al. (1985), "Complementary DNA Sequences Of Ovarian Follicular Fluid Inhibin Show Precursor Structure And Homology With Transforming Growth Factor.beta.," 318 Nature, 659-663.
Cate et al. (1986) "Isolation of the Bovine and Human Genes for Mullerian Inhibiting Substance and Expression of the Human Gene in Animal Cells," 45 Cell 685-698.
Edelman (1986), "Cell Adhesion Molecules in the Regulation of Animal Form and Tissue Pattern," 2 Ann. Rev. Cell Biol 81-116.
Miller et al. (1987), "Phenotypic Modulation of the Swarm Rat Chondrosarcoma Induced by Morphogenetic Bone Matrix.sup.1," 42 Cancer Research 2589-3594.
Padgett et al. (1987), "A Transcript From A Drosophila Pattern Gene Predicts A Protein Homologous To The Transforming Growth Factor-.beta. Family," 325 Nature 81-84.
Weeks et al. (1987), "A Maternal mRNA Localized to the Vegetal Hemisphere in Xenopus Eggs Codes for a Growth Factor Related to TGF-.beta.," 51 Cell 861-867.
Wang et al.; Wozney et al.; and Rosen et al. (1988), "Purification and Characterization of Cartilage and Bone Inducing Factors;" "Identification Through Molecular Cloning of Factors Involved in In Vivo Cartilage Formation;" and "Developmental Expression of Cartilage and Bone-Specific Genes In The Rat Embryo," 42 Calcified Tissue Int. (Suppl.): Abstract Nos. 146, 147 and 136.
Wang et al. (1988), "Purification and Characterization of Other Distinct Bone-Inducing Factors" 85 Proc. Natl. Acad. Sci. USA, 9484-9488.
Wozney et al. (1988), "Novel Regulators of Bone Formation: Molecular Clones and Activities," 242 Science 1528-1534.
Ausubel et al. (1989) "Current Protocols in Molecular Biology," (John Wiley & Sons, N.Y.).
Lyons et al. (1989), "Patterns Of Expression Of Murine Vgr-1 And BMP-2a RNA Suggest That Transforming Growth Factor-.beta.-Like Genes Coordinately Regulate Aspects of Embryonic Development," 3 Genes & Development 1657-1668.
Lyons et al. (1989), "Vgr-1, A Mammalian Gene Related to Xenopus Vg-1, Is A Member Of The Transforming Growth Factor .beta. Gene Superfamily," 86 Proc. Natl. Acad. Sci. USA 4554-4558.
Mason et al. (1989), "Activin B: Precursor Sequences, Genomic Structure and in Vitro Activities," 3 Mol. Endocrinology 1352-1358 (1989).
Rosen et al. (1989), "Purification and Molecular Cloning of a Novel Group of BMPS and Localization of BMP MRNA In Developing Bone," 20 Connect. Tissue Res. 1-4:313-319.
Behringer et al. (1990), "Abnormal Sexual Development In Transgenic Mice Chronically Expressing Mullerian Inhibiting Substance," 345 Nature 167-170.
Celeste et al. (1990), "Identification of Transforming Growth Factor Beta Family Members Present in Bone-Inductive Protein Purified from Bovine Bone," 87 Proc. Nat. Acad. Sciences USA 9843-9847.
Green et al. (1990), "Graded Changes In Dose Of A Xenopus Activin A Homologue Elicit Stepwise Transitions In Embryonic Cell Fate," 347 Nature 391-394.
Katagiri et al. (1990), "The Non-Osteogenic Mouse Pluripotent Cell Line, C3H10T1/2 is Induced to Differentiate Into Osteoblastic Cells by Recombinant Human Bone Morphogenetic Protein-2," 172 Biochem Biophys. Res. Comm. 1:295-299.
Lee (1990), "Identification of a Novel Member (GDF-1) of the Transforming Growth Factor-.beta. Superfamily," 90 Mol. Endrocr. 1034-1040.
Ozkaynak et al. (1990), "OP-1 cDNA Encodes An Osteogenic Protein In The TGF-.beta. Family," 9 EMBO J. 2085-2093.
Panganiban et al. (1990), "Biochemical Characterization of the Drosophila dpp Protein, A Member of the Transforming Growth Factor .beta. Family of Growth Factors," 10 Mol. Cell. Biol. 2669-2677.
Rosen et al.; Celeste et al. (1990), "In Vivo and In Vitro Roles of BMP in Skeletal Formation and Repair;" "Highly Purified Bovine Bone-Inductive Activity Contains Multiple Protein Species Related to BMP-2," J. Cell Biochem. Suppl. 14E, 33 (Abstract No. 004); 54 (Abstract No. 105).
Sampath et al. (1990), "Bovine Osteogenic Protein Is Composed of Dimers of OP-1 and BMP-2A, Two Members of the Transforming Growth Factor-.beta. Superfamily," 265 J. Biol. Chem. 13198-13205.
Schubert et al. (1990), "Activin Is A Nerve Cell Survival Molecule," 344 Nature 868-870.
Smith et al. (1990), "Identification Of A Potent Xenopus Mesoderm-Inducing Factor As A Homologue Of Activin A," 345 Nature 729-731.
Sokol et al. (1990), "A Mouse Macrophage Factor Induces Head Structures and Organizes a Body Axis in Xenopus," 249 Science 561-563.
Wang et al. (1990), "Recombinant Human Bone Morphogenetic Protein Induces Bone Formation," 87 Proc. Natl. Acad. Sci. USA 2220-2224.
Wozney (1990), "Bone Morphogenic Proteins," 1 Prog. In Growth Factor Res. 267-280.
Wozney et al. (1990), "Growth Factors Influencing Bone Development," 13 J. Cell Sci. Suppl. 149-156.
Yannas (1990), "Biologically Active Analogues of the Extracellular Matrix: Artificial Skin and Nerves," 29 Angew. Chem. Int. Ed. Engl. 20-35.
D'Allesandro et al. (1991), "Purification, Characterization and, Activity of Recombinant Human BMP-5," J. Cell. Biochem. Suppl. 166 (Abstract No. Q105).
Israel et al. (1991), "Expression of Recombinant BMP-2 in Chinese Hamster Ovary Cells," J. Cell. Biochem. Suppl. 168 (Abstract No. Q-111).
Lee (1991), "Expression Of Growth/Differentiation Factor 1 In The Nervous System: Conservation Of A Bicistronic Structure," 88 Proc. Natl. Acad. Sci. USA 4250-4254.
Takuwa et al. (1991), "Bone Morphogenetic Protein-2 Stimulates Alkaline Phosphatase Activity and Collagen Synthesis in Cultured Osteoblastic Cells, MC3T3-E1," 174 Biochem. Biophys. Res. Comm. 1:96-101.
Ozkaynak et al. (1991), "Murine Osteogenic Protein-1 (OP-1): High levels of mRNA in Kidney," 179 Biochem. Biophys. Res. Comm. 116-123.
Wharton et al. (1991), "Drosophila 60A Gene, Another Transforming Growth Factor .beta. Family Member, is Closely Related to Human Bone Morphogenetic Proteins," 88 Proc. Natl. Acad. Sci. USA 9214-9218.
Yamaguchi et al. (1991), "Recombinant Human Bone Morphogenetic Protein-2 Stimulates Osteoblastic Maturation and Inhibits Myogenic Differentiation In Vitro," 113 J. Cell Biol. 3:681-687.
Israel et al. (1992), "Expression and Characterization of Bone Morphogenetic Protein-2 in Chinese Hamster Ovary Cells," 7 Growth Factors 139-150.
Rogers et al. (1992), "Bone Morphogenetic Proteins-2 and -4 are Involved In The Retinoic Acid-Induced Differentiation of Embryonal Carcinoma Cells," 3 Mol. Biol. Cell 2:189-196.
Thies et al. (1992), "Recombinant Human Bone Morphogenetic Protein-2 Induces Osteoblastic Differentiation in W-20-17 Stromal Cells," 130 Endocrinology 3:1318-1324.
Wozney et al.; Celeste et al.; Rosen et al. (1992), "Regulation of Chondrogenesis and Osteogenesis by the BMP Proteins," "Molecular Cloning of BMP-8: A Protein Pre
Cohen Charles M.
Kuberasampath Thangavel
Oppermann Hermann
Ozkaynak Engin
Pang Roy H. L.
Schwartzman Robert A.
Stryker Corporation
LandOfFree
OP-3 induced morphogenesis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with OP-3 induced morphogenesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and OP-3 induced morphogenesis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1725908