Process for preparing halo triazolo benzodiazepine

Details Process for preparing halo triazolo benzodiazepine Process for preparing halo triazolo benzodiazepine

1976-09-26

1976-11-09

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D48704

Patent

active

039910709

ABSTRACT:
Preparing 1-halo-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines by reacting an N-halosuccinimide with a 2-[3-(phthalimidomethyl)triazolyl]benzophenone to form the 2-[5-halo-3-(phthalimidomethyl)triazolyl] benzophenone and reacting the 2-[5-halo-3-(phthalimidomethyl)triazol-4-yl]benzophenone with hydrazine or a primary amine in an organic liquid solvent medium at 25.degree. to 100.degree. C. The products of the process have CNS tranquilizer and sedative properties but are also of interest for use as intermediates to prepare 2,4-dihydro-6-phenyl-1H-s-triazolo[4,3-a] [1,4]benzodiazepin-1-ones which are of clinical interest for their CNS tranquilizer, sedative and anti-depressant drug use properties in mammalian animals including humans.

REFERENCES:
patent: 3709899 (1973-01-01), Hester
patent: 3842090 (1974-10-01), Gall et al.
patent: 3880878 (1975-04-01), Hester
patent: 3882139 (1975-05-01), Gall et al.
patent: 3891666 (1975-06-01), Hester

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