Process for making 3-formylcephem derivatives

Details Process for making 3-formylcephem derivatives Process for making 3-formylcephem derivatives

1995-12-18

1997-05-20

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540230, C07D50126

Patent

active

056313667

ABSTRACT:
The present invention is concerned with a novel process for the making of a compound of formula I ##STR1## by oxidizing the corresponding 3-hydroxymethyl-cephem derivative with an inorganic hypohalite or inorganic halite in the presence of compounds of formula III ##STR2## is wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and Y are as defined herein.
The process is useful for providing 3-formyl-cephem compounds useful in the making of cephalosporin derivatives.

REFERENCES:
patent: 3984401 (1976-10-01), Terao et al.
Inokuchi, et al., J. Org. Chem., 55(2):462-466 (1990).
Anelli, Pier Lucio, et al., J. Org. Chem., 52:2559-2562 (1987).
Anelli, Pier Lucio, et al., Organic Syntheses, Coll, 8:367-371 (1993).
Green, T., Protective Groups In Organic Synthesis, Chap. 5, John Wiley and Sons, Inc., pp. 152-192, 218-287 (1981).
Inokuchi, Tsutomu, J. Org. Chem., 56:2416-2421 (1991).
Inokuchi, Tsutomu, Chemistry Letters, pp. 1411-1414 (1994).
Rozantsev, Eduard, G., et al., Synthesis, pp. 190-202 (1971).

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