Penicillin antibiotics

Details Penicillin antibiotics Penicillin antibiotics

1975-09-11

1976-11-09

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D49968

Patent

active

039910466

ABSTRACT:
The invention provides novel antibiotic compounds which are 6.beta.-acylamidopenam-3-carboxylic acids and non-toxic derivatives thereof, characterized in that the acylamido group has the structure ##EQU1## WHERE R is a hydrogen atom or an organic group and R.sup.a is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

REFERENCES:
Chem. Abstr., vol. 70, Col. 77850(c) (1969).
Arkiv Forkemi, 22(33), pp. 451-467 (1964).
Acta Chemsca Scandinavica 19, pp. 281-299 (1965).

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