Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-04-28
1997-05-20
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142352, 514253, 514255, 514314, 514339, 514381, 514383, 514384, 514394, 514397, 514414, 548495, 548496, A61K 3140, C07D20920
Patent
active
056312814
ABSTRACT:
Novel unnatural dipeptoids of .alpha.-substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, colorectal tumors, or as antipsychotics are disclosed. Further the compounds are antianxiety agents, antiulcer agents, antidepressant agents, and are agents useful for preventing the withdrawal response produced by chronic treatment or use followed by chronic treatment followed by withdrawal from nicotine, diazepam, alcohol, cocaine, caffeine, or opiods. Also disclosed are pharmaceutical compositions and methods of treatment using the dipeptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare pharmaceutical and diagnostic compositions.
REFERENCES:
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Voelter et al "1-(1-adamantyl-1-methylethoxycarbonyl a new group for amino protection of peptide" CA 94:140148v(1981).
Int J Cancer, 57, 1994, 1-7.
Proc. Natl. Acad. Sci., v. 87, pp. 6728-6732, Sep. 1990, J. Hughes et al., "Development of a Class of Selective Cholecystokinin Type B . . . ".
Trends in Pharmacological Sciences, vol. 11, Jul. 1990, pp. 271-273, Cholecystokinin and Anxiety.
Aranda Julian
Horwell David C.
Pritchard Martyn C.
Richardson Reginald S.
Roberts Edward
Anderson Elizabeth M.
Chang Ceila
Warner-Lambert & Company
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