Methods and preparations for the treatment and prophylaxis of me

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514351, A61K 3144

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active

056312717

ABSTRACT:
Treatment or prophylaxis of depressed or inadequate intracellular pyridoxal phosphate levels in a human or animal patient resulting from a condition, wherein the pyridoxine (PN)--pyridoxal phosphate (PLP) pathway is disturbed by cellular defects and concomitant enzyme deficiencies. These may be due to genetic causes or cell immaturity, as occurs in infants and in diseases resulting in erythrocytes destruction. In infants it was found, for the first time, that this leads to elevated homocysteine levels.
The deficiencies are counteracted by the administration of pyridoxal or a precursor of pyridoxal which in vivo, once it has entered the bloodstream, is rapidly convened into pyridoxal without the intervention of oxidase or oxygen, optionally and preferably without the intervention of kinase and/or of PN in slow-release form and at a daily dosage rate not exceeding 0.7 mg/kg/day in the long term.
In the case of pharmaceutical or dietary preparations for infants, in particular premature infants, these contain in addition vitamin B12 and folic acid or folate.

REFERENCES:
patent: 5254572 (1993-10-01), Serfontein
Dialog File 446, 001148023, 1962.
Dialog File 446, 01238461, 1968.
L. Brattstrom, et al. Atherosclerosis 81 (1990) 51-60.
L. Brattstrom, et al. Scand J Clin Lab Invest 1988: 48215-211.
AJ Olszewski, et al., Atherosclerosis, 75 (1989) 1-6.

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