Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1999-06-17
2000-11-28
McKelvey, Terry
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
435243, 4353201, 435325, 435468, 435471, 435410, 536 231, 536 234, 536 2372, C12N 1564, C12N 100, C12N 510, C12N 1534, C12N 1563
Patent
active
061534358
ABSTRACT:
The present invention provides a chimeric adenoviral coat protein (particularly a chimeric adenovirus hexon and/or fiber protein). The chimeric adenovirus coat protein has a decreased ability or inability to be recognized by a neutralizing antibody directed against the corresponding wild-type adenovirus coat protein. The invention also provides an adenovirus comprising a chimeric adenovirus coat protein, and methods of constructing and using such an adenovirus, for instance, in gene therapy.
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Crystal Ronald G.
Falck-Pedersen Erik
Gall Jason
Kovesdi Imre
Wickham Thomas J.
Cornell Research Foundation Inc.
GenVec, Inc.
McKelvey Terry
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