Human immunodeficiency virus co-receptor variants associated wit

Details Human immunodeficiency virus co-receptor variants associated wit Human immunodeficiency virus co-receptor variants associated wit

1998-05-28

2000-11-28

Budens, Robert D.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435455, 435325, 435354, 435366, 435372, 4353201, 536 234, 536 235, C12N 510, C07H 2104

Patent

active

061534315

ABSTRACT:
The present invention relates to variants of the CCR5 human immunodeficiency virus ("HIV") co-receptor which result in a resistance of CCR5 expressing cells to HIV infection. The detection of such mutations may be used to identify individuals at lower risk for infection relative to the general population who, if infected, may exhibit slower progression to AIDS. Further, the present invention provides for methods of inhibiting HIV infection of a cell expressing the CCR5 receptor, comprising introducing, into the cell, a nucleic acid encoding a CCR5 variant.

REFERENCES:
Quillent et al., Lancet 351:14-18, Jan. 3, 1998.
Benkirane et al., Dec. 1997, "Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5.DELTA.32", J. Biol. Chem. 272:30603-30606.
Alkhatib et al., Jun. 1996, "CC CKR5: A RANTES, MIP-1.alpha., MIP-1.beta. receptor as a fusion cofactor for macrophage-tropic HIV-1", Science 272:1955-1958.
Choe et al., Jun. 1996, "The .beta.-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates" Cell 85:1135-1148.
Dean et al., Sep. 1996, "Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene" Science 273:1856-1862.
Deng et al., Jun. 1996, "Identification of a major co-receptor for primary isolates of HIV-1" Nature 381:661-666.
Doranz et al., Jun. 1996, "A dual-tropic primary HIV-1 isolate that uses fusin and the .beta.-chemokine receptors CKR-5, CKR-3 and CKR-2b as fusion cofactors" Cell 85:1149-1158.
Dragic et al., Jun. 1996, "HIV-1 entry into CD4.sup.+ cells is mediated by the chemokine receptor CC-CKR-5" Nature 381:667-673.
Liu et al., Aug. 1996, "Homozygous defect in HIV-1 coreceptor accounts for resistance of some multipy-exposed individuals to HIV-1 infection" Cell 86:367-377.
Samson et al., 1996, "Molecular cloning and functional expression of a new human cc-chemokine receptor gene" Biochemistry 35:3362-3367.
Samson et al., Aug. 1996, "Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene" Nature 382:722-725.
Cocchi et al., Dec. 1995, "Identification of RANTES, MIP-1.alpha., and MIP-1.beta. as the major HIV-suppressive factors produced by CD8.sup.+ cells" Science 270:1811-1815.

Affiliated with

Also associated with

Rating

Human immunodeficiency virus co-receptor variants associated wit does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human immunodeficiency virus co-receptor variants associated wit, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human immunodeficiency virus co-receptor variants associated wit will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1724120