Process for producing 5-fluorouracil

Details Process for producing 5-fluorouracil Process for producing 5-fluorouracil

1985-03-07

1986-12-23

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

260694, C07D23922

Patent

active

046313427

ABSTRACT:
A process for producing 5-fluorouracil using an aqueous phosphoric acid solution as a solvent which is a good solvent for an intermediate resulting from the reaction between uracil and elemental fluorine, and permits the reaction to proceed smoothly, but which can precipitate the final product, 5-fluorouracil, after cooling the heat-treated reaction solution to room temperature, with no need to evaporate the solvent.
The process comprises reacting uracil in an aqueous phosphoric acid solution with elemental fluorine and heating the resultant reaction solution to form 5-fluorouracil.

REFERENCES:
patent: 3682917 (1972-08-01), Knuniants et al.
patent: 3846429 (1974-11-01), Giller et al.
patent: 3954758 (1976-05-01), Schuman et al.
patent: 4029661 (1977-06-01), Schuman et al.
patent: 4082752 (1978-04-01), Takahara et al.
patent: 4524032 (1985-06-01), Misaki et al.

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