Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-05
1997-05-20
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530399, C07K 1461, A61K 3827
Patent
active
056312270
ABSTRACT:
The present invention provides analogs of somatotropins wherein the asparagine residue corresponding to position 99 of a bovine somatotropin is replaced with a compound selected from the group consisting of proline, aspartic acid, glutamic acid, serine, glycine, serine-serine or serine-aspartic acid. Particularly preferred analogs are bovine somatotropin and their use to increase milk production.
REFERENCES:
patent: 4521409 (1985-06-01), Bauman
patent: 5089473 (1992-02-01), Kriri et al.
patent: 5130422 (1992-07-01), Kriri et al.
Lewis et al., Biochem. Biophys. Acta, 214, 498-508, 1970.
Biochemistry 27: 4541-4546 (1988), Brems.
Abdel-Meguid et al., Proc. Natl. Acad. Sci., 84, 6434-6437, 1987.
West et al., Textbook of Biochemistry, 4th ed., The Collier-Macmillan Co. N.Y. 1966, p. 1467.
Lewis et al., Biochem. Biophys. Acta, 214 pp. 498-508 (1970).
West et al, Textbook of Biochemistry, 45th ed., The Collier-MacMillan Co., NY, 1966 p. 1467.
Takano et al., Chem Abst., 99, 107, Abst. #64639s.
Paladini, A.C., et al., Molecular Biology of Growth Hormone, CRC Critical Reviews in Biochem., 15:25-56 (1983).
Hart, I.C., et al., The Hetergeneity of Bovine Growth Hormone, Biochem. J., 218-573-581 (1984).
Wallis, M., et al., A Chromatographic Preparation of Ox Growth Hormone, Biochem., J., 100:593-600 (1966).
Lewis, U.J., et al., Kinetic Study of the Deamidation of Growth Hormone and Prolactin, Biochim, Biophys. Acta, 214:498-508 (1970).
Nucleic Acid Res. 10(20):6487 (1982).
Winter, G. and Fersht, A.R., TIBS, 2 p. 115 (1984).
Chou, P.Y. and Fasman, G.D., Ann. Rev. Biochem., 47, pp. 251-276 (1978).
Chou, P.Y. and Fasman, G.D., J. Mol. Biol., 115, pp. 135-175 (1977).
Garlick Robert L.
Harbour Gary C.
Hoogerheide John G.
Lyle Stephen B.
Mott John E.
Darnley, Jr. James D.
Koivuniemi Paul J.
Schain Howard E.
Steele Gregory W.
The Upjohn Company
LandOfFree
Somatotropin analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Somatotropin analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Somatotropin analogs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1723910