Methods for screening for transdominant intracellular effector p

Details Methods for screening for transdominant intracellular effector p Methods for screening for transdominant intracellular effector p

1997-01-23

2000-11-28

Chan, Christina Y.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 435 701, 435 911, 435325, 536 231, 536 243, 536 2431, 536 245, C12Q 168, C12P 1934, C12N 500, C07H 2104

Patent

active

061533807

ABSTRACT:
Methods and compositions for screening for intracellular transdominant effector peptides and RNA molecules selected inside living cells from randomized pools are provided.

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Pear et al., "Production of High-Titer Helper-Free Retroviruses by Transient Transfection," PNAS USA, 90:8392-8396 (1993).
Palzkill et al., "Selection of Functional Signal Peptide Cleavage Sites from a Library of Random Sequences," J. Bacteriology, 563-568 (1994).
Scott and Craig, "Random Peptide Libraries," Current Opinion in Biotechnology, 5:40-48 (1994).
Hupp et al., "Small Peptides Activate the Latent Sequence-Specific DNA Binding Function of p53," Cell, 83:237-245 (1995).
Cadwell and Joyce, "Randomization of Genes by PCR Mutagenesis," Abstract excerpted from: PCR Methods and Applications, 2(1):28-33 (1992) (Abstract No. XP 002033396).
Fong et al., "Scanning Whole Cells with Phage-Display Libraries: Identification of Peptide Ligands that Modulate Cell Function," Drug Development Research, 33:64-70 (1994).

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