Method of determining incompatibility-reaction-causing substance

Details Method of determining incompatibility-reaction-causing substance Method of determining incompatibility-reaction-causing substance

1989-09-26

1993-08-10

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

435 4, 435 3, 435 29, 435269, 435 88, 514 2, 514 1, A61K 3900, C12Q 100, C12Q 300, C07K 300

Patent

active

052346854

ABSTRACT:
There is disclosed a method of determining the presence of incompatibility-reaction-causing substances in blood products. There is also disclosed a method of inactivating incompatibility-reaction-causing substances in blood products to be applied therapeutically and prophylactically. For this purpose, a fraction obtained from human or animal blood is treated with pancreas enzymes bound to water insoluble carrier material and, optionally, the fraction is subjected to further fractionation and concentration.

REFERENCES:
patent: 4276283 (1981-06-01), Eibl et al.
patent: 4371612 (1983-02-01), Matsumoto et al.
Workshop on Subchronic Toxicity Testing (1980) Proceedings of the Workshop EPA-5601/11-80-028.
Ed Page et al, Springfield Va.: National Technical Information Series. As referenced in Lu (1985) Basic Toxicology. Hemisphere Inc, Washington. pp. 99-112.
"Proceedings of the Workshop on Subchronic Toxicity Testing", Denver Colorado, May 20-24, 1979.

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