Method for promoting epithelial healing and prevention of epithe

Details Method for promoting epithelial healing and prevention of epithe Method for promoting epithelial healing and prevention of epithe

1986-03-11

1989-07-18

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514802, 424101, A61K 3702

Patent

active

048494062

ABSTRACT:
A method of determining the presence of epithelial lesions is provided wherein a sample of a body fluid taken from an epithelial region suspected to have said lesions is tested for the presence of a proteolytic activity. The lesion is then treated by applying a therapeutically effective amount of a proteinase inhibitor in the form of a physiologically acceptable preparation, a pharmaceutical preparation of aprotinin being particularly preferred.

REFERENCES:
patent: 4171377 (1979-10-01), Green et al.
patent: 4377572 (1983-03-01), Schwarz et al.
patent: 4592997 (1986-06-01), Wilhelms et al.
Heine et al., cited in Chem. Abstracts, 101:148914a 1984.
Nakagawa et al., cited in Chem. Abstracts 105:131609q 1986.
Zirm, Klin. Mbl. Augenheilk, 177 (1980) pp. 759-764.
Berman et al., Investigative Ophthamology and Visual Science, vol. 24, (1983) pp. 1358-1366.

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