Withania somnifera composition

Details Withania somnifera composition Withania somnifera composition

1999-07-13

2000-11-28

Prats, Francisco

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

A61K 3578

Patent

active

061531987

ABSTRACT:
A high purity Withania somnifera extract composition in the form of a high purity, stable, free-flowing, light yellow-to-brown herbaceous powder, for producing an enhanced cognition effect for the user and to augment the learning facility in the geriatric population when taken in a dosage of 200-800 mg/day. This extract contains, by weight, (a) at least 3% of withanolide glycosides and sitoindosides, preferably 3-8%, (b) at least 3% of oligosaccharides, preferably 3-8%, preferably a molecular weight of <2000, and (c) less than 0.5% of free cytotoxic withaferin A (aglycone), wherein the ratio of (a):(c) is 75-95:25-5, and the ratio of (a):(b) is 40-60:60-40. An extraction process for obtaining such extract composition, and pharmaceutical and nutritional use products thereof, also are described.

REFERENCES:
patent: 5494668 (1996-02-01), Patwardhan
"Anti-Stress Activity of Sitoindosides VII and VIII, New Acylsterylglucosides from Withania Somnifera", Phytother. Res. 1, 32-37 (1987) S.K. Bhattacharaya et al.
Immunomodulatory and CNS Effects of Sitoindosides IX and X, Two New Glycowithanolides from Withania Somnifera, Phytother. Res. 3, 201-206 (1989), S. Ghosal et al.
"Natural Products with Immunological Effects", Indian J. Indigenous Medicine 8, 1-7 (1991), S. Ghosal.
"Effects of Glycowithanolides from Withania Somnifera on Morphine-Induced Inhibition of Intestinal Motility and Tolerance to Analgesia in Mice", Phytother. Res. 9, 66-68 (1995), P. Ramarao et al.
"Effects of Glycowithanolides from Withania Somnifera on an Animal Model of Alzheimer's Disease and Preturbed Central Cholinergic Markers of Cognition in Rats", Phytother. Res. 9, 110-113 (1995).
"Antioxidant Activity of Glycowithanolides", Indian J. Exp. Biol. 35, 236-239 (1997), S. K. Bhattacharya et al.
"Systemic Administration of Defined Extracts from Withania Somnifera (Indian Ginseng) and Shilajit Differentially Affects Cholinergic but not Glutamatergic and Gabaergic Markers in Rat Brain", Neurochem. Int. 30, 181-190 (1997), R. Schleibs et al.
"Role of Withania Somnifera (Ashwagandha) in Various Types of Arthropathies", Indian J. Med. Res. 56, 1581-1583 (1968), N. P. Bector et al.

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