Method of treating human breast cancer by administration of radi

Details Method of treating human breast cancer by administration of radi Method of treating human breast cancer by administration of radi

1995-06-29

1998-06-16

Feisee, Lila

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

4241381, 4241521, 4241551, 4241571, 4241781, 5303913, 5303877, 5303888, 53038885, 5303897, A61K 39395, A61K 5100, A61K 3100

Patent

active

057665710

ABSTRACT:
An improved in vivo method of inhibiting or retarding the growth of malignant tumor cells in a subject comprises administering the subject antitumor therapy, the improvement comprising administering to the subject at least one product comprising an agent selected from the group consisting of polyunsaturated fatty acids, prostaglandins, prostacyclins, thromboxanes, leukotrienes, malone-aldehyde, triene epoxides, analogs thereof, salts thereof and mixtures thereof, the antitumor therapy and the product being administered in amounts and for a period of time effective to attain the desired effect. An in vivo method of inhibiting or retarding the growth of malignant tumor cells comprises administering to a subject in need of such treatment at least one anti-cell antigen specific radiolabeled antibody and at least one product comprising an agent such as polyunsaturated fatty acids, prostaglandins, prostacyclins, thromboxanes, leukotrienes, malonealdehyde, triene epoxides, salts thereof and mixtures thereof, the antibody and the product being administered in amount and for a period of time effective to attain the desired effect. A kit for use in antitumor therapy comprises in separate containers an antitumor agent such as a chemotherapeutic agent, an antitumor hormonal agent, an anti-target cell antibody, external and an internal irradiation agents, or biological response modifiers, and an agent such as polyunsaturated fatty acids, prostaglandins, prostacyclins, thromboxanes, leukotrienes, malonealdehyde, triene epoxides, salts thereof or mixtures thereof.

REFERENCES:
Peterson, J.A., et al., "Biochemical and Histological Characterization of Antigens Preferentially Expressed on the Surface and Cytoplasm of Breast Carcinoma Cells Identified by Monoclonal Antibodies Against the Human Milk Fat Globule", Hybridoma 9:221-235 (1990).
Kramer, E. L. et al, "Radioimmunolocalization of Metastatic Breast Carcinoma Using Indium-111-Methyl Benzyl DTPA BrE-3 Monoclonal Antibody: Phase 1 Study" Radioimmunolocalization of Breast Cancer 34:1067-1074 (1993).
Mooi, W.J., et al, "Accessibility of antigenic sites recognized by AUA1, HMFG1 and HMFG2 mononclonal antibodies: its influence on antibody binding of live cells", The Int. J. of Biological Markers 2:57-63 (1987).
Bamias, A. et al "Intravesical Administration of Indium-111-Labelled HMFG2 Monoclonal Antibody in Superficial Bladder Carcinomas" Int. J. Cancer 54:899-903 (1993).
Epenetos, A.A. et al "Antibody-Guided Irradiation of Advanced Ovarian Cancer With Intraperitoneally Administered Radiolabeled Monoclonal Antibodies" J. of Cl. Oncology 5:1890-1899 (1987).
Kalofonos, H.P. et al "Antibody-Guided Diagnosis and Therapy of Malignant Lesions" Int. J. Cancer; Suppl 2:74-80 (1988).
Kosmas, H.P. et al "Radiolabelled Monoclonal Antibodies in Tumor Diagnosis and Therapy" Develop. biol. Standard 71:93-102 (1990).
Athanassiou, A. et al "Immunoscintigraphy with .sup.131 I-Labelled HMFG.sub.2 and HMFG.sub.1 F(ab').sub.2 In the Pre-Operative Detection of Clinical and Subclinical Lymph Node Metastases in Breast Cancer Patients" Int. J. Cancer, Suppl 3:89-95 (1988).
Pectasides, D. et al "Immunoscintigraphy with .sup.131 I-Labelled HMFG.sub.2 and HMFG.sub.1 F(ab').sub.2 Versus Abdominal CT Scan in the Detection of Residual Disease in Ovarian Cancer Patients" Int. J. Cancer, Suppl 3:83-88 (1988).
Pervez, S. et al "Localization of Monoclonal Antivbody AUA1 and Its F(ab').sub.2 Fragments in Human Tumor Xenografts: An Autoradiographic and Immunohistochemical Study" Int. J. Cancer Suppl 3:23-29 (1988).
Shepherd, J. et al "Tumour-associated monoclonal antibodies for the diagnosis and assessment of ovarian cancer" Br. J. of Ob/Gyn 94:160-167 (1987).
Dhokia, B. et al "A new Immunoassay using monoclonal antibodies HMFG1 and HMFG2 together with an existing marker CA125 for the serological detection and managmeent of epithelial ovarian cancer" Br. J. Cancer 54:891-895 (1986).
Dhokia, B. et al "A low pH enzuyme linked immunoassay using two monoclonal antibodies for the serological detection and monitoring of breast cancer" Br. J. Cancer 54:885-889 (1986).
Epenetos, A.A., et al, "Targeting of Iodine-123-Labelled Tumour-Associated Monoclonal Antibodies to Ovarian, Breast, and Gastrointestinal Tumours", The Lacet, 6 Nov. 1982: 999-1004.
"Effect of Fish Oil on Prostaglandin E and Tumor Lipid in a Human Mammary Carcinoma", Ceriani, R.L., Peterson, J.A., John Muir Cancer and Aging Research Institute, Draft #8: 1-29 (Aug. 5, 1991).
Blank, E.W., et al., "Fish Oil Enhancement of 131-Conjugated Anti-Human Milk Fat Globule Monoclonal Antibody Experimental Radioimmunotherapy of Breast Cancer", J. Steroid Biochem., vol. 34, Nos. 1-6, pp. 149-153 (1989).
Ceriani, R.L., et al, "Immunotherapeutic Preclinical Evaluation of Anti-Human Milk Fat Globule MoAbs MC5 & BrE-1", Antibody, Immunoconjugates, & Radiopharmaceuticals vol. 3, No 3: 181-198 (1990).
Ceriani, R.L., et al, "Development and Characterization of Breast Carcinoma Cell Lines as in Vitro and in Vivo Models for Breast Cancer Diagnosis and Therapy", Program Project Grant: Breast Cancer Therapy 1-P01-CA42767, Appendix 6:1-29, (May 13, 1991).
Ceriani, R.L., et al, "Biodistribution and Radioimmunotherapy in Eight Antibodies against the Breast Epithelial Mucin with Diverse Characteristics Labeled with .sup.131 In, .sup.111 In and .sup.90 Y", Program Project Grant: Breast Cancer Therapy 1-P01-CA42767, Appendix 7:1-41 (1991).
DeNardo, S.J.., et al, "Radioimmunotherapy with I-131 Chimeric L-6 in Advanced Breast Cancer", In: Breast Epithelial Antigens: Molecular Biology Clinic Application, Ceriani, R.L., e.d., Plenum Publishing, pp. 227-232 (1991).
Ceriani, R.L., & Blank, E.W., "Experimental Therapy of Human Breast Tumors with .sup.131 I-Labeled Monoclonal Antibodies Prepared against the Human Milk Fat Globule", Cancer Research 48;4664-4672 (1988).
Peterson, J.A., et al, "Biochemical and Histological Characterization of Antigens Preferentially Expressed on the Surface and Cytoplasm of Breast Carcinoma Cells Identified by Monoclonal Anti-bodies Against the Human Milk Fat Globule", Hybridoma 9(3):221-235 (1990).
Ceriani, R.L., et al, "Experimental Immunotherapy of Human Breast Carcinomas Implanted in Nude Mice with a Mixture of Monoclonal Antibodies Against Human Milk Fat Blobule Components", Cancer Research 47:532-540 (Jan. 15, 1987).
Ceriani, R.L., et al., "Characterization of Cell Surface Antigens of Human Mammary Epithelial Cells with Monoclonal Antibodies Prepared Against Human Milk Fat Globule", Somatic Cell Genetics 9(4):415-427 (1983).
"Proceedings of the AOCS Short Course on Polyunsaturated Fatty Acids and Eicosanoids", Lands, W.E.M., Ed., American Oil Chemists' Society, Champaign, IL, May 14-17, 1987 in Biloxi, MS.
CRC Handbook of Eicosanoids: Prostaglandins and Releated Lipids, vol. 1, Chamical and Biochemical Aspects, Part A, Willis, A.L., Eds., CRC Press Inc., pp. 3-46 Boca Raton FL (1987).
Karmall et al., J. Nat. Cancer Inst. 73:457 (1984).
Begin et al., J. Nat. Cancer Inst. 9:188 (1988).
Reitz et al in Proceedings of the AOCS Short Course on Polyunsaturated Fatty Acids and Eicosanoids, Ed. Lands, W.E.M, American Oil Chemists'Society, Champaign, Illinois; pp. 529-533 (1987).
Wetherall et al, "Antiproliferative Effect of Vitamin A on Xenotransplanted CaMa-15 Cells", Cancer Res., 44, 2393-2397 (1984).
Fraker et al, "Growth Inhibition by Retinol of a Human Breast Carcinoma Cell line in Vitry and in Athymic Mice", Cancer Res., 44, 5757-5763, (Dec. 1984).
Blank, E.W. et al., "A Novel Anti-breast Epithelial Mucin MAb (BrE-3). Characterization and Experimental Biodistribution and Immunotherapy", The Cancer Journal, vol. 5 No. 1 38-44 (1992).
De Nardo, S.J. et al., "Treatment of B Cell Malignants with .sup.131 ILYM-1 Monoclonal Antibodies", Int. J. Cancer, Suppl. 3,96-101 (1988).
Peterson, J.A. et al., "Molecular Analysis of Epitopic Heterogeneity of the Breast Mucin". In: Breast Epithelial Antigens., Ed. by Ceriani, R.L., Plenum Press, New York, pp. 55-68 (1991).
Ceriani, R.L. et al., "Breats Epithelial Antigen Levels and Breast Tumor An

Affiliated with

Also associated with

Rating

Method of treating human breast cancer by administration of radi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of treating human breast cancer by administration of radi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating human breast cancer by administration of radi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1721723