Substituted glutamic acids

Details Substituted glutamic acids Substituted glutamic acids

1988-04-15

1990-07-10

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 16, 514 17, 514 18, 514 19, 514908, 544321, 2609982, 530331, 530330, 530329, A61K 31505, C07D23949, C07D23936

Patent

active

049407139

ABSTRACT:
The present invention provides a compound of formula (I): ##STR1## wherein R.sup.1 is hydrogen, C.sub.1-4 alkyl, acetyl or formyl; R.sup.2 and R.sup.3 are the same or different and are hydrogen or C.sub.1-4 alkyl; R.sup.4 is NR.sup.11 R.sup.12 ; R.sup.11, R.sup.12, R.sup.5 and R.sup.6 are the same or different and are hydrogen, C.sub.1-4 alkyl or C.sub.1-12 acyl; R.sup.7, R.sup.8, R.sup.9 and R.sup.10 are the same or different and are hydrogen, halo, C.sub.1-4 haloalkyl, C.sub.1-4 alkyl and C.sub.1-4 alkoxy; and n is 2, 3, 4 or 5; m is 0 or an integer from 1 to 6; or a salt thereof, methods for the preparation of the compounds of the formula (I), intermediates in their preparations, pharmaceutical formulations containing them, and their use in the treatment of tumors.

REFERENCES:
patent: 4369319 (1983-01-01), DeGraw et al.
patent: 4833145 (1989-05-01), Taylor et al.
patent: 4880812 (1989-11-01), Kelley
Koehler et al, J.A.C.S. vol. 80, pp. 5779-5786 (1958) "Potential Anticancer Agents. IX. Tetrahydroquinazoline . . . ".
Baker et al, J. of Pharm. Sci., vol. 52, No. 9, 1963, pp. 840-843, "Analogs of Tetrahydrofolic Acid".
Berezovskij et al, Khim. Farm. Zh., vol. 1, No. 6 (1967) pp. 5-9.

Affiliated with

Also associated with

Rating

Substituted glutamic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted glutamic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted glutamic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1721088