Imidazoles and pharmaceutical composition

Details Imidazoles and pharmaceutical composition Imidazoles and pharmaceutical composition

1976-08-02

1977-11-15

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

260250AH, 260250BN, 2602564C, 2602564R, 2602564N, 260268H, 2602937, 260302H, 2603067T, 2603068D, 544 60, 544139, 544194, 544212, 548313, 548309, C07D40314, C07D27738, A61K 3138

Patent

active

040586170

ABSTRACT:
Imidazoles of the formula I ##STR1## wherein one of the radicals R.sub.1 and R.sub.2 denotes hydrogen or lower alkyl and the other denotes the nitro group, R.sub.3 is lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, lower alkylsulphonyl-lower alkyl or amino-lower alkyl, R.sub.4 is oxo or thioxo, R.sub.5 -- if R.sub.1 is the nitro group -- is hydrogen, lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, amino-lower alkyl, acyl, aryl or a heterocyclic radical or R.sub.5 -- if R.sub.2 is the nitro group -- is aryl or a heterocyclic radical, with the exception of an optionally substituted 2-imidazolyl group, and alk is lower alkylene and their therapeutically usable salts, S-oxides, sulphones or N-oxides are useful as agents against amoebae, schistosomes, filariae, trichomonades and bacteria and as intermediates.

REFERENCES:
patent: 3452035 (1969-06-01), Berkelhammer et al.
patent: 3798232 (1974-05-01), Wittekind et al.

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