Aliphatic 2-decarboxy-2-hydroxymethyl-13,14-didehydro-PG compoun

Details Aliphatic 2-decarboxy-2-hydroxymethyl-13,14-didehydro-PG compoun Aliphatic 2-decarboxy-2-hydroxymethyl-13,14-didehydro-PG compoun

1976-07-26

1977-11-15

Morgenstern, Norman

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260590C, 260611R, 260611A, 260613R, 260613D, 260617R, 260617E, 260618E, 260618R, 424331, 424339, 424340, 424341, 424343, C07C 3506, C07C 4327, C07C 4946, C07C 4958

Patent

active

040585646

ABSTRACT:
This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol and the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.

REFERENCES:
patent: 3932496 (1976-01-01), Jung
patent: 3935254 (1976-01-01), Gandolfe et al.
patent: 3984400 (1976-10-01), Egglev et al.
Fried et al., "J. Med. Chem.," vol. 16, No. 4, pp. 429-430 (1973).

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