Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1976-03-23
1977-11-15
Daus, Donald G.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260289D, 260289C, C07D22128, C07D21724, C07D49108
Patent
active
040585310
ABSTRACT:
N-substituted-14-hydroxy-3-substituted-morphinan derivatives have been found to possess potent narcotic agonist or antagonist activity. In particular, the compound N-Cyclobutylmethyl-3,14-dihydroxymorphinan has been found to possess potent agonist/antagonist activity as a non-narcotic analgesic. A new and efficient total synthesis of these compounds is described herein from the starting material 2-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline.
REFERENCES:
patent: 2723268 (1955-11-01), Henecka
patent: 3786054 (1974-01-01), Murikami et al.
patent: 3919237 (1975-11-01), Halder
Onda, et al., Chemical & Pharmaceutical Bulletin, 21 (11), pp. 2359-2365, (1973).
Bachand Carol
Monkovic Ivo
Wong Henry
Bristol-Myers Company
Daus Donald G.
Rivers Diana G.
Uloth R. H.
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