Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1985-05-21
1989-07-18
Kepplinger, Esther M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436501, 436518, 436808, 436810, 435188, 435805, 435810, G01N 33535, G01N 33543
Patent
active
048493384
ABSTRACT:
An assay method and compositions are provided for determining the presence of an analyte in a sample. The analyte is a member of an immunological pair (mip) comprising ligand and receptor. By providing a first measurement surface capable of specifically binding a labelled reagent in an amount depending upon the presence of analyte in the sample and a second calibration surface capable of binding a second labeled reagent in a manner unaffected by the presence of analyte in the sample, calibration of individual tests can be accomplished simultaneously with the performance of the test itself. A signal producing system includes an enzyme, a catalyst usually bonded to a mip which defines the first labeled reagent for binding to the measurement surface and the same catalyst conjugated to a ligand capable of binding to the calibration surface. Preferably, both labeled reagents have the same composition and the calibration surface include anti-(first catalyst).
REFERENCES:
patent: 4299916 (1981-11-01), Litman et al.
patent: 4315907 (1982-02-01), Fridlender et al.
patent: 4366241 (1982-12-01), Tom et al.
patent: 4378344 (1983-03-01), Zahradnik et al.
patent: 4391904 (1983-07-01), Litman et al.
patent: 4533629 (1985-08-01), Litman et al.
patent: 4540659 (1985-09-01), Litman et al.
Litman David J.
Ullman Edwin F.
Kepplinger Esther M.
Leitereg Theodore J.
Syntex (U.S.A.) Inc.
LandOfFree
Simultaneous calibration heterogeneous immunoassay does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Simultaneous calibration heterogeneous immunoassay, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Simultaneous calibration heterogeneous immunoassay will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-171697