Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs t

Details Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs t Tetrahydrothienopyridine derivatives, furo and pyrrolo analogs t

1992-09-08

1994-02-22

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546114, A01K 314, C07D51304

Patent

active

052887260

ABSTRACT:
Compounds of formula (I): ##STR1## wherein: R.sup.1 is hydrogen, alkyl, halogen, haloalkyl, hydroxy, alkoxy, haloalkoxy, alkylthio, haloalkylthio, amino, alkanoyl, haloalkanoyl, carboxy, alkoxycarbonyl, carbamoyl, cyano, nitro, alkanesulfonyl, haloalkanesulfonyl or sulfamoyl; R.sup.2 is optionally substituted alkanoyl, optionally substituted alkenoyl, optionally substituted cycloalkylcarbonyl, substituted benzoyl, or 5,6-dihydro-1,4,2-dioxazin-3-yl; R.sup.3 is hydrogen, hydroxy, optionally substituted alkoxy, aralkyloxy, alkanoyloxy, alkenoyloxy, cycloalkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aralkyloxycarbonylxy, phthalidyloxy, (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy, (5-phenyl-2-oxo-1,3-dioxolen-4-yl)methoxy, optionally substituted amino or nitro; Y is --NH-- or oxygen or sulfur; n is 1 to 5; and tautomers and salts of said compounds of formula (I), have the ability to inhibit blood platelet aggregation, and can thus be used for treatment and prophylaxis of thrombosis and embolisms.

REFERENCES:
patent: 4051141 (1977-09-01), Castaigne
patent: 4075215 (1978-02-01), Castaigne
patent: 4127580 (1978-11-01), Braye
patent: 4136186 (1979-01-01), Frehel et al.
patent: 4458074 (1984-07-01), Bouscuet et al.
patent: 4464377 (1984-08-01), Blanchard et al.
patent: 4529596 (1985-07-01), Aubert et al.
patent: 4740510 (1988-04-01), Badorc et al.

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