Raman-based system for DNA sequencing-mapping and other separati

Details Raman-based system for DNA sequencing-mapping and other separati Raman-based system for DNA sequencing-mapping and other separati

1992-08-24

1994-04-26

Niebling, John

Chemistry: electrical and wave energy

Processes and products

Electrostatic field or electrical discharge

204299R, G01N 27447, G01N 2726

Patent

active

053064038

ABSTRACT:
DNA sequencing and mapping are performed by using a Raman spectrometer with a surface enhanced Raman scattering (SERS) substrate to enhance the Raman signal. A SERS label is attached to a DNA fragment and then analyzed with the Raman spectrometer to identify the DNA fragment according to characteristics of the Raman spectrum generated.

REFERENCES:
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Theodora W. Greene, Protective Groups In Organic Synthesis, John Wiley & Sons 1981.
Giulietta Smulevich et al. "Surface-Enhanced Resonance Raman Spectra of Adriamycia, 11-Deoxycarminomycin, Their Model Chromophores, and Their Complexes with DNA" Journal of Physical Chemistry, vol. 90, No. 23 (1986) 6388-6392.
Therese M. Cotten et al. "Determination of Purine Bases by Reversed-Phase High Performance Liquid Chromatography Using Real-Time Surface-Enhanced Raman Spectroscopy" Analytical Chemistry, vol. 63, No. 5 (1991) 437-442.
Jean-Marie L. Sequaris et al. "Direct Analysis of High-Performance Thin-Layer Chromatography Spots of Nucleic Purine Derivatives by Surface-Enhanced Raman Scattering Spectrometry" Analytical Chemistry, vol. 59, No. 3 (1987) 525-527.
R. Ken Force et al. "Surface-Enhanced Raman Spectroscopy at a Silver Electrode as a Detection System in Flowing Streams" Analytical Chemistry, vol. 62, No. 7 (1990) 678-680.
Therese M. Cotton et al. "Flow Injection Analysis and Real-Time Detection of RNA Bases by Surface-Enhanced Raman Spectroscopy" Analytical Chemistry, vol. 62, No. 18 (1990) 1958-1963.

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