Novel 9-deoxy-16,16-dimethyl-PGF.sub.2 compounds, intermediates

Details Novel 9-deoxy-16,16-dimethyl-PGF.sub.2 compounds, intermediates Novel 9-deoxy-16,16-dimethyl-PGF.sub.2 compounds, intermediates

1979-05-18

1980-09-02

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

26050115, 26050118, 542426, 562503, 424305, 424316, 424317, C07C17700

Patent

active

042207975

ABSTRACT:
The present invention provides novel 9.alpha.-methyl- or 9.beta.-methyl-9-deoxy-16,16-dimethyl-PGF.sub.2 compounds, and novel processes and intermediates for their preparation. Further provided are novel intermediates for the preparation of known 9-deoxy-9-methylene-16,16-dimethyl-PGF.sub.2 compounds. The novel 9.alpha.- or 9.beta.-methyl-9-deoxy-16,16-dimethyl-PGF.sub.2 compounds are usefully employed as highly selective gastro-intestinal smooth muscle stimulators, rendering these novel compounds useful in the treatment of paralytic intestinal and bladder diseases. The novel compounds also possess the further advantage of exhibiting these gastro-intestinal smooth muscle effects, with reduced uterotonic and intestinal enteropooling effects as compared to the known 9-deoxy-PGF compounds.

REFERENCES:
patent: 4033989 (1977-07-01), Bundy

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