Use of boron supplements to increase in vivo production of hydro

Details Use of boron supplements to increase in vivo production of hydro Use of boron supplements to increase in vivo production of hydro

1988-04-20

1989-07-18

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Boron

424660, A61K 3322

Patent

active

048492205

ABSTRACT:
The oral administration of boron compounds such as sodium borate and boric acid increases the amounts of hydroxylated steroids in human plasma. This will help prevent or alleviate pathology, such as osteoporosis, caused by suboptimal circulating hydroxylated steroids such as 17.beta.-estradiol and testosterone.

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Forrest H. Nielsen et al., "Effect of Dietary Boron on Mineral, Estrogen, and Testosterone Metabolism in Postmenopausal Women," FASEB J. 1: 394-397, (1987).
Judy McBride, "Banishing Brittle Bones with Boron?" Agricultural Research, Nov./Dec. 1987, pp. 12-13.
Terrence R. Shuler et al., "Interactions Among Boron, Calcium, and Magnesium in Rats: Plasma and Bone Mineral Content," Abstract 91, Proc. North Dakota Acad. Sci. 40: 81, (Apr. 1986).
Forrest H. Nielsen, "Boron Affects Magnesium Deprivation and Aluminum Toxicity in Rats," Abstract 92, Proc. North Dakota Acad. Sci. 40: 82, (Apr. 1986).
C. D. Hunt et al., "Dietary Boron Affects Molybdenum and Magnesium Metabolism in the Cholecalciferol Deficient Chick," Abstract 93, Proc. North Dakota Acad. Sci., 40: 83, (Apr. 1986).
Forrest H. Nielsen, "Other Elements: Sb, Ba, B, Br, Cs, Ge, Rb, Sr, Sn, Ti, Zr, Be, Bi, Ga, Au, In, Nb, Sc, Te, Tl, W," In Trace Elements in Human & Animal Nutrition, vol. 2, Academic Press, New York, pp. 420-427, 454-463, (1986).
Rex E. Newnham, "Mineral Imbalance and Boron Deficiency," In Trace Element Metabolism in Man and Animals, 4: 400-402, Aust. Acad. Sci. Canberra, (1981).
J. A. Jansen et al., "Gastro-Intestinal Absorption and in vitro Release of Boric Acid from Water-Emulsifying Ointments," Fd. Chem. Toxic, 22(1): 49-53, (1984).
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