Process of preparing 3-phenyl-quinoline-5-carboxylic acid

Details Process of preparing 3-phenyl-quinoline-5-carboxylic acid Process of preparing 3-phenyl-quinoline-5-carboxylic acid

1992-11-03

1993-12-14

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549304, C07D21514

Patent

active

052704696

ABSTRACT:
A process for preparing 3-phenyl-quinoline-5-carboxylic acid comprising reacting 4-amino-3-hydroxyphthalide with phenylacetaldehyde.

REFERENCES:
patent: 4730056 (1988-03-01), Lowe, III
patent: 5130434 (1992-07-01), Hagen et al.
Chemical Abstracts, vol. 78, No. 1, Jan. 8, 1973, Columbus, Ohio, USA Watanabe, Tokuhiro et al. "Indoles, III. New synthesis of 4-indolecarboxylic acid." p. 339, col. 1, para. No. 4 058h.
Chemical Abstracts, vol. 80, No. 25, Jun. 1974, Columbus, Ohio, USA Aoki, Katsumichi et al., "Fungicidal compositions containing 4-chlorophthalide derivatives." p. 84, col. 2, para. No. 141791x.
Chemical Abstracts, vol. 90, No. 23, Jun. 4, 1979, Columbus, Ohio, USA Houbion, J. A. et al. "The synthesis of unamiguously substituted 3-hydroxyphthalides." p. 640, col. 2, para. No. 186 703t.
Chemical Abstracts, vol. 104, No. 1, Jan. 6, 1986, Columbus, Ohio, USA Sloan, Kenneth B. et al. "Further reactions of 3-hydroxy-1(3H)-isobenzofuranone with amines." p. 523, col. 1 para. No. 5 724q.
J. Org. Chem. 1988, 53, 223-224.
J. Org. Chem. 1988, 53, 1199-1202.
J. of Med. Chem., 1988, vol. 31, No. 4, 824-830.
T. Watanabe et al., Chem. Pharm. Bull, 20(10), 2123-2127 (1972).

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