Barbiturate derivatives and protein and polypeptide barbiturate

Details Barbiturate derivatives and protein and polypeptide barbiturate Barbiturate derivatives and protein and polypeptide barbiturate

1992-04-06

1995-05-09

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544301, C07D23962, C07D40912

Patent

active

054140854

ABSTRACT:
The present invention is directed to novel barbiturate derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to the barbiturate metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.

REFERENCES:
Forster, Acta Biol. Med. Germ., vol. 9 (1962) pp. 497-516.
K. Foerster, et al., Chemical Abstracts 58:10665e, abstract of Acta Biol. Med. Ger., 9, 497-516, 1962 (Ger) (1963).
Kotva, Rudolf et al., 5,5-Disubstituted Barbituric Acids and Their Analogues, Collection Czechoslovak Chem. Comm. 181:137-143 (1983).

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