Treatment of arthritis, including rheumatoid arthritis with .sup

Details Treatment of arthritis, including rheumatoid arthritis with .sup Treatment of arthritis, including rheumatoid arthritis with .sup

1987-01-28

1989-07-18

Terapane, John F.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

534 10, 423249, 600 5, A61N 512, A61K 4300, A61K 4902

Patent

active

048492094

ABSTRACT:
.sup.1/3 Holmium in a carrier metallic hydroxide aggregate is disclosed for the treatment of arthritis and, in particular, rheumatoid arthritis. The compound disclosed preferably has a particle size of 1 to 40 microns, Beta energy emissions in the range of 1.76-1.84 MeV, low levels of gamma ray emissions and a radioactive half-life of 26.8 hours. The preferred metallic hydroxide is selected from the group consisting of Ferric Hydroxide, Aluminum Hydroxide, Bismuth Hydroxide, Chromium Hydroxide, Cupric Hydroxide, Manganese Hydroxide and Stannous Hydroxide. Methods are also disclosed for the preparation of the compound, as well as for the methods of its administration to a patient in need thereof.

REFERENCES:
patent: 3961038 (1976-06-01), Benes
patent: 4752464 (1988-06-01), Lieberman et al.
patent: 4758929 (1988-07-01), Gordon
Hackh's Chemical Dictionary, 4th Ed., McGraw-Hill, p. 168 (1969).
Sledge et al., Radiation Synovectony, No. 152 (1984), pp. 37-40.
Sledge et al., Arthritis and Rheumatism, vol. 20(7), pp. 1334-1342 (1977).

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