Fluoro-amide derivatives

Details Fluoro-amide derivatives Fluoro-amide derivatives

1990-05-07

1993-12-14

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514256, 514269, 514274, 514275, 514336, 514346, 514352, 514354, 514355, 514444, 514445, 514446, 514447, 514448, 514471, 514472, 514473, 530331, 544298, 544316, 544330, 544331, 544332, 544335, 546283, 546284, 546291, 546309, 546314, 546316, 549444, 549445, 549446, 549447, 549448, 549472, 549473, 549479, 549480, 549487, 564 91, A61K 3702, A61K 31505, A61K 3144, A61K 3138, A61K 3134, C07D23902, C07D21306, C07D21346, C07D31744, C07D30702

Patent

active

052703010

ABSTRACT:
The present invention relates to certain fluoro-amide derivatives, as described herein, which are human leukocyte elastase (HLE) inhibitors making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated, including treatment of tissue degenerative diseases such as pulmonary emphysema. The invention also includes intermediates useful in the synthesis of these fluoro-amide derivatives, processes for preparing them, pharmaceutical compositions containing such peptide derivatives and methods for their use.

REFERENCES:
patent: 4256761 (1981-03-01), Suh et al.
patent: 4880780 (1989-11-01), Trainer et al.
patent: 4910190 (1990-03-01), Bergeson et al.
patent: 4923890 (1990-05-01), Trainor et al.
J. L. Stanton et al., J. Med. Chem. (1983) 26, 1267-1277.
J. T. Suh et al., J. Med. Chem. (1985) 28, 57-66.
S. M. Weldon et al., FASEB J. (1990) 4 (4), Abstract 5212.

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