Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-09-20
1995-05-09
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514333, 546256, 546273, A61K 3144, C07D40106, C07D40114
Patent
active
054140048
ABSTRACT:
Compounds of the following formula have been shown to enhance the release of the neurotransmitter acetylcholine, and thus may be useful in the treatment of diseases of man involving learning and cognition, where subnormal levels of this neurochemical are found ##STR1## wherein R.sup.1 is 4-,3-, or 2-pyridyl, 2-fluoro-4-pyridyl or 3-fluoro-4-pyridyl;
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Cook et al., Drug Dev. Res. 1990, 19:301.
Nickolson et al., Drug Dev. Res. 1990, 19:285.
DeNoble et al., Pharm. Biochem. Behav. 1990, 36:957.
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Saletu et al., Chem. Abstracts. 1989, 111:108875p.
Earl Richard A.
Voss Matthew E.
Wilkerson Wendell W.
Boudreaux Gerald J.
Henley III Raymond
Spivack Phyllis G.
The Du Pont Merck Pharmaceutical Company
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