Drug screening and treatment for HIV thymocyte depletion

Details Drug screening and treatment for HIV thymocyte depletion Drug screening and treatment for HIV thymocyte depletion

1994-01-18

1997-03-18

Chambers, Jasemine C.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Testing efficacy or toxicity of a compound or composition

424553, 424577, 424580, 424582, 800 2, 800DIG2, 800DIG5, A61K 4900

Patent

active

056120184

ABSTRACT:
A method is provided for screening compounds for the ability to supress thymocyte depletion in thymuses of HIV-infected individuals, particularly enhancing the CD4.sup.+ -expressing population as compared to an untreated individual. Particularly, drugs are provided which allow for this result, cyclosporine A being exemplary.

REFERENCES:
McCune, Cell 64: 351-363 (1991).
McCune et al. (b), Annual Reviews in Immunology 9: 399-429 (1991).
McCune et al. (c), Science 247: 564-566 (1990).
Kaneshima et al., Nature 348: 561-562 (1990).
Namikawa et al. (a), J. Exp. Med. 172: 1055-1063 (1990).
Namikawa et al. (b), Science 242: 1684-1686 (1988).
McCune et al. (a), Science 241: 1632-1639 (1988).

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