Controlled release ACTH containing microspheres

Details Controlled release ACTH containing microspheres Controlled release ACTH containing microspheres

1994-06-30

1995-05-09

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424422, 424423, 424424, 424426, 424486, 424434, 514769, 514772, 5147723, 514805, 514963, A61K 952, A61K 3740, A61K 950

Patent

active

054137977

ABSTRACT:
ACTH polymeric controlled release systems are described wherein the ACTH retains good biological activity and is released over an extended period of time following administration by injection. In the preferred embodiment, the ACTH polymeric microspheres are made using very cold temperatures to freeze the polymer-ACTH mixtures into polymeric microspheres with very high retention of biological activity and material. Sustained release of biologically active ACTH is achieved when the microspheres are tested in vitro, extending over a period of greater than one day to several months. Altered release can be achieved by inclusion of degradation modifiers, pore forming agents, and stabilizers of the ACTH.

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