Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-10-13
1995-05-09
Naff, David M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
424 941, 424 9464, 435 13, 435183, 435219, 514453, 514492, 514502, 514802, 529210, A61K 3748, A61K 31295, A01N 4316
Patent
active
054137861
ABSTRACT:
Blood coagulation is accelerated by contacting blood with an accelerator of hydrolase activity. The activation of the precursors of serine protease including Factor XII and the enzyme activity of serine protease is accelerated. The accelerator is a metal complex containing a ligand which is a cyclic compound having a five- or six-membered ring containing carbonyl groups adjacent to each other. Examples of such ligands are oxidized alkylgallate, partially or totally oxidized ellagic acid, partially or completely oxidized 1,4- di(3,4-dihydroxyphenyl) 2,3-dimethylbutane, 1,2,3-triketohydroindene and isatin. The metal of the complex is preferably Fe, Co, Ni, or Al. The complex may be combined with a hydrolase as a co-accelerator of coagulation, an organic acid having an amino salt and/or a quaternary nitrogen or an antifibrinolysis agent and/or an anti-plasmin agent.
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Lankford L. Blaine
Naff David M.
Sekisui Kagaku Kogyo Kabushiki Kaisha
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