Receptor modulating agents

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 2644, 514 52, C12P 1942, A61K 3168

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active

058408800

ABSTRACT:
Receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway. The receptor modulating agents are comprised of a covalently bound rerouting moiety and targeting moiety.

REFERENCES:
patent: 4167556 (1979-09-01), Selhub et al.
patent: 5196510 (1993-03-01), Rodwell et al.
patent: 5310656 (1994-05-01), Pourfarzneh et al.
patent: 5428023 (1995-06-01), Russel-Jones et al.
Thiele, Dwain L., et al., "The Role of Leucyl-Leucine Methyl Ester-Sensitive Cytotoxic Cells in Skin Allograft Rejection, " Transplantation, Vol. 53, No. 6, Jun. 1992, pp. 1334-1340.
Akin, Cem, et al., "Modulation of Transferrin Receptor Expression by Insulin and Granulocyte-Macrophage Colony Stimulating Factor in AML-193 Leukemic Cells," Cancer Letters, vol. 69, 1993, pp. 51-57.
Anderson, Richard G.W., et al., "Potocytosis: Sequestration and Transport of Small Molecules by Caveolae, " Science,vol. 255, 24 Jan. 1992, pp. 410-411.
Krautler, Bernard, et al., "Oligomethylene-Bridged vitamin B.sub.12 Dimmers," Angewandt Chemie International Edition English, vol. 34, No. 1, 1995, pp. 84-86.
Takahashi, Kiyoshi, et al., "Receptor Binding and Internalization of Immobilized Transcobalamin II by Mouse Leukaemia Cells," Nature, vol. 288, no. 18, Dec. 25, 1980, pp. 713-715.
Carpentier, Jean-Louis, et al.,"Potassium Depletion and Hypertonic Medium Reduce `Non-Coated` and Clathrin-Coated Pit Formation, as Well as Endocytosis Through These Two Gates," Journal of Cellular Physiology, vol. 138, 1989, pp. 519-526.
Ciechanover, Aaron, "The Ubiquitin-Proteasome Proteolytic Pathway," Cell, vol. 79, Oct. 7, 1994, pp. 13-21.
Gratzer, W.B., et al., "The Red Blood Cell and Malaria Parasite Invasion," Seminars in Hematology, vol. 30, No. 3, Jul. 1993, pp. 232-247.
Jabbar, M. Abdul, et al., "Intracellular Interaction of Human Immunodeficiency Virus Type 1 (ARV-2) Envelope Glycoprotein gp160 with CD4 Blocks the Movement and Maturation of CD4 to the Plasma Membrane," Journal of Virology, vol. 64, No. 12, Dec. 1990, pp. 6297-6304.
Joly, Marguerite, et al., "Disruption of PDGF Receptor Trafficking by Mutation of its PI-3 Kinase Binding Sites," Science, vol. 263, 4 Feb. 1994, pp. 684-687.
Kreiner, Thane, et al., "Membrane Traffic Between Secretory Compartments is Differentially Affected During Mitosis," Cell Regulation, vol. 1, Apr. 1990, pp. 415-424.
Malorni, Walter, et al., "Menadione-Induced Oxidative Stress Leads to a Rapid Down-Modulation of Transferrin Receptor Recycling," Journal of Cell Science, vol. 106, 1993, pp. 309-318.
Mayor, Satyajit, et al., "Sequestration of GPI-Anchored Proteins in Caveolae Triggered by Cross-Linking, "Science, vol. 264, 24 Jun. 1994, pp. 1948-1951.
Mayor, Satyajit, et al., "Sorting of Membrane Components from Endosomes and Subsequent Recycling to the Cell Surface Occurs by a Bulk Flow Process," The Journal of Cell Biology, vol. 121, No. 6, Jun. 1993, pp. 1257-1269.
Parton, Robert G., et al., "Regulated Internalization of Caveolae," The Journal of Cell Biology, vol. 127, No. 5, Dec. 1994, pp. 1199-1215.
Robertson, Barbara J., et al., "Role of Vesicular Traffice in the Transport of Surface Transferrin Receptor to the Golgi Complex in Cultured Human Cells," Archives of Biochemistry and Biophysics, vol. 292, No. 1, Jan. 1992, pp. 190-198.
Ross, John F., et al, "Differential Regulation of Folate Receptor Isoforms in Normal and Malignant Tissues In Vivo and in Established Cell Lines," Cancer, vol. 73, No. 9, May 1, 1994, pp. 2432-2443.
Schnitzer, Jan E., et al., "Filipin-Sensitive Caveolae-Mediated Transport in Endothelium: Reduced Transcytosis, Scavenger Endocytosis, and Capillary Permeability of Select Marcomolecules," The Journal of Cell Biology, vol. 127, No. 5, Dec. 1994, pp. 1217-1232.
Sigal, Nolan H., et al., "Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction," Annual Review Immunology, vol. 10, 1992, pp. 519-560.
Smart, Eric J., et al., "Caveolin Moves from Caveolae to the Golgi Apparatus in Response to Cholesterol Oxidation," The Journal of Cell Biology, vol. 127, No. 5, Dec. 1994, pp. 1185-1197.
Sorkin, Alexander, et al., "Endocytosis of Growth Factor Receptors," BioEssays, vol. 15, No. 6, Jun. 1993, pp. 375-382.
Sorkin, Alexander, et al., "Interaction of Activated EGF Receptors with Coated Pit Adaptins,"Science, vol. 261, 30 Jul. 1993, pp. 612-615.
Toraya, Tetsuo, et al., "Preparation, Properties and Biological Activities of Succinyl Derivatives of Vitamin B.sub.12," Bioinorganic Chemistry, vol. 4, 1975, pp. 245-255.
Trowbridge, I.S., et al., "Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway," Annual Review Cell Biology, vol. 9, 1993, pp. 129-161.
Wang, Ji Ming, et al., "Studies of Binding and Internalization of Human Recombinant Monocyte Chemotactic and Activating Factor (MCAF) by Monocytic Cells," Cytokine, vol. 5, No. 3 (May), 1993, pp. 264-275.
White, Suhaila, et al., "Combinations of Anti-Transferrin Receptor Monoclonal Antibodies Inhibit Human Tumor Cell Growth in Vitro and in Vivo: Evidence for Synergistic Antiproliferative Effects, "Cancer Research, vol. 50, Oct. 1, 1990, pp. 6295-6301.
Ying, Y.-S., et al., "Each Caveola Contains Multiple Glycosyl-Phosphatidylinositol-Anchored Membrane Proteins," Cold Spring Harbor Symposia on Quantitative Biology, vol. 57, 1992, pp. 593-604.
Ashworth, Rachel, et al., "Visualization of the Thyrotropin-Releasing Hormone Receptor and its Ligand During Endocytosis and Recycling," Proceedings of the National Academy of Science USA, vol. 92, Jan. 1995, pp. 512-516.
Cavallaro, Ugo, et al., "Targeting Plant toxins to the Urokinase and .alpha..sub.2 -Macroglobulin Receptors," Seminars in Cancer Biology, vol. 6, 1995, pp. 269-278.
Mclean et al. Analogs of Cobalamin inhibit the growth of Lekemia in Vitro pp. 1-20.
Pignatello et al, Self-Association of Organocoalamins in Aqeous Solution J. Chem. Soc. Dalton Trans. pp. 1381-1387, 1985.
Pathare et al. Synthesis of Cobalamin Dimers Using Isophthalate crosslinking of Corrin Ring Carboxlates and Evaluation of their Binding to Transcobalamin, Bioconjugate Chem. vol. 8, No. 2, pp. 161-172, 1997.

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