Arteriosclerosis depressant

Details Arteriosclerosis depressant Arteriosclerosis depressant

1996-11-22

1998-11-24

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3141

Patent

active

058407413

ABSTRACT:
by the following formula; ##STR1## and the physiologically-acceptable salts thereof showed to have excellent inhibitory effect on the proliferation of vascular smooth muscle cells and are effective to prevent the occurrence of restenosis after the operation of PTCA, and hence the compounds can be useful for the therapeutic and preventive treatment for arteriosclerosis and other diseases whereto the proliferation of vascular smooth muscle cells is directly concerned.

REFERENCES:
Ross, The Pathogenesis of Atherosclerosis-an Update, N. Engl. J. Med., 314, 488-500 (1986).
Gyires, et al., The effect of some anti-ulcer agants on the vascular injury of gastovic mucosa induced by ethanol in rats, Acta Physio. Hung., 73 (2-3), (1989), pp. 149-154.
Definition of Arteriosclerosis, Hirokawa Pharmaceutics Dictionary 2.sup.nd edition, p. 971.
Ross, et al., The Pathogenesis of Atherosclerosis, N. Engl. J. Med., 295, 369-377 (1976).
Ross, et al., The Pathogenesis of Atherosclerosis, N. Engl. J. Med., 295, 420-425 (1976).

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