Sex steroid activity inhibitors

Details Sex steroid activity inhibitors Sex steroid activity inhibitors

1994-08-03

1998-11-24

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514319, 514358, 514211, 514510, 514200, 5142222, 514196, 514456, 546196, 546205, A61K 31445, A61K 3144, A61K 31545, C07D40100

Patent

active

058407359

ABSTRACT:
Inhibitors of sex steroid activity, for example those having the general structure ##STR1## may be used as part of a pharmaceutical composition to provide antiestrogenic effects and/or to suppress estrogen synthesis. Such pharmaceutical compositions are useful for the treatment of breast cancer or other diseases whose progress is aided by activation of sex steroid receptors.

REFERENCES:
patent: 2875199 (1959-02-01), Cella
patent: 3321483 (1967-05-01), Crenshaw et al.
patent: 3396169 (1968-08-01), Lednicer et al.
patent: 3471520 (1969-10-01), Irmscher et al.
patent: 3597431 (1971-08-01), Coppola et al.
patent: 3995060 (1976-11-01), Neri
patent: 4094994 (1978-06-01), Schonenberger
patent: 4139638 (1979-02-01), Neri
patent: 4161540 (1979-07-01), Neri
patent: 4368080 (1983-01-01), Crossley
patent: 4472382 (1984-09-01), Labrie
patent: 4659516 (1987-04-01), Bowler
patent: 4659695 (1987-04-01), Labrie
patent: 4732912 (1988-03-01), Pilgrim
patent: 4751240 (1988-06-01), Bowler
patent: 4760061 (1988-07-01), Edwards
patent: 4904661 (1990-02-01), Pilgrim et al.
patent: 4950684 (1990-08-01), Koszyk et al.
patent: 4963568 (1990-10-01), Schoenleber et al.
patent: 4975455 (1990-12-01), Brion et al.
patent: 5021432 (1991-06-01), Yamanaka et al.
patent: 5098903 (1992-03-01), Magarian et al.
patent: 5204337 (1993-04-01), Labrie et al.
patent: 5407947 (1995-04-01), Bryant et al.
Jones et al., Journal of Medicinal Chemistry, vol. 22, No. 8 (1979).
Dhar, et al., Contraception, vol. 44, No. 4, (1991) pp. 461-472.
Stoessel, et al., Journal of Steroid Biochem., vol. 25, No. 5A (1986) pp. 677-682.
Crenshaw, et al., Journal of Medicinal Chemistry, vol.14, No. 2 (1971) pp. 1185-1190.
Pruitt, et al., Organic Prep. and Proc. Int'l vol. 22, No. 2 (1990) pp.235-244.
CA:113(23)--No. 211775W p. 744, Dec. 1990--Sharma, et al.
CA:117(9)--No. 90146p p. 90147, Sep. 1992--Kapil, et al.
CA:86(1)--No. 5271Z p. 5280, Jan. 1977--Badran, et al.
CA:107--No. 154111(b) p. 678, Oct. 1987--Alberola, et al.
Asselin, et al., J. Steroid Biochem. 9:1079-1081(1978).
Auchus, et al., Biochemistry 25:7295-7300 (1986).
Bhatnagar, et al., J. Biol. Chem. 253:811-815 (1978).
Blickenstaff, et al., Steroids 46:889-902 (1985).
Bucourt, et al., J. Biol. Chem. 253:8221-8228 (1978).
Chin, et al., J. Biol. Chem. 250:7682-7686 (1975).
Chin, et al., J. Biol. Chem. 255:3660-3664 (1980).
Durani, et al., J. Med. Chem. 32:1700-1707 (1989).
Furr, et al., J. Endocr. 113:R7-R9 (1987).
Jordan, et al., Endocrinology 124:1717-1726 (1989).
Klijn, et al., J. Steroid Biochem. 20(6B):1381, No. A33 (Abstr.) (1984).
Poulin, et al., Cancer Res. 46:4933-4937 (1986).
Saeed et al., J. Med. Chem. 33:3210-3216 (1990).
Sharma, et al., J. Med. Chem. 33:3216-3229 (1990).
Simard, et al., Mol. Cell. Endo. 39:141-144 (1985).
Simard, et al., Mol. Cell. Endo. 2:775-784 (1988).
Simard, et al., Endocrinology 126:3223-3231 (1990).
Thomas, et al., J. Biol. Chem. 258:1587-1590 (1983).
Thomas, et al., J. Biol. Chem. 258:11500-11508 (1983).
Tobias, et al., J. Biol. Chem. 257:2783-2786 (1982).
von Angerer, et al., J. Med. Chem. 33:2635-2640 (1990).
von Angerer, et al., J. Med. Chem. 27:1439-1447 (1984).
Wakeling, et al., Cancer Res. 51:3867-3873 (1991).
Wakeling, et al., J. Endo. 112:R7-R10 (1987).
Wakeling, et al., Steroid Biochem. 30:141-147 (1988).

Affiliated with

Also associated with

Rating

Sex steroid activity inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sex steroid activity inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sex steroid activity inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1702550