Inhibitors of collagenase-1 and stormelysin-I metalloproteases,

Details Inhibitors of collagenase-1 and stormelysin-I metalloproteases, Inhibitors of collagenase-1 and stormelysin-I metalloproteases,

1995-10-27

1998-11-24

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, 564154, A61K 3800, A61K 3806

Patent

active

058406980

ABSTRACT:
Disclosed are novel inhibitors of collagenase-1 and stromelysin-I metalloproteases. The disclosed inhibitors are mercaptoketone and mercaptoalcohol compounds which are useful in pharmaceutical compositions and methods for treating or controlling disease states or conditions which involve tissue breakdown, for example, arthropathy, dermatological conditions, bone resorption, inflammatory diseases, and tumor invasion and in the promotion of wound healing.

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