Process for producing 7-amino-6-demethyl-6-deoxytetracycline

Details Process for producing 7-amino-6-demethyl-6-deoxytetracycline Process for producing 7-amino-6-demethyl-6-deoxytetracycline

1988-06-03

1989-07-18

Hollrah, Glennon H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603513, C07C 49423

Patent

active

048491365

ABSTRACT:
This invention provides a new process for producing 7-amino-6-demethyl-6-deoxytetracycline (Compound 3) which is an intermediate for the synthesis of minocycline.
Compound 3 can be obtained by reduction of Compound 1 using a dithionite as reducing agent.
This invention also provides a method to produce Compound 3 from Compound 2 in one pot. ##STR1## (wherein Ar denotes a substituted aryl group, and X stands for the residue of a mineral acid from which hydrogen atom has been eliminated).

REFERENCES:
patent: 3043875 (1962-07-01), Beereboom et al.
patent: 3226436 (1965-12-01), Petisi et al.
patent: 3239499 (1966-03-01), Rennhard et al.
patent: 3341585 (1967-09-01), Bitha et al.
patent: 3403179 (1968-09-01), Zambrano
patent: 3901942 (1975-08-01), Bernardi et al.
J. Org. Chem., 36, 723 (1971).
J. Med. Chem., 10, 44 (1967).
J. Med. Pharm. Chem., 5, 538 (1962).
Farmaco. Ed. Sci., 30, 736 (1975).

Affiliated with

Also associated with

Rating

Process for producing 7-amino-6-demethyl-6-deoxytetracycline does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing 7-amino-6-demethyl-6-deoxytetracycline, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing 7-amino-6-demethyl-6-deoxytetracycline will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-170048