Unsymmetrical esters of N-substituted 1,4-dihydropyridine 3,5-di

Details Unsymmetrical esters of N-substituted 1,4-dihydropyridine 3,5-di Unsymmetrical esters of N-substituted 1,4-dihydropyridine 3,5-di

1974-08-13

1976-01-20

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602948C, 2602948F, 2602948G, 2602949, 2602955R, 2602955B, 424266, C07D21355

Patent

active

039338347

ABSTRACT:
Unsymmetrical esters of N-substituted 4-substituted-1,4-dihydropyridine 3,5-dicarboxylic acid substituted in the 4-position by pyridyl, thienyl, furyl and pyrryl and optionally substituted in the 2- and 6-positions by lower alkyl. The products can be prepared (A) through condensation of an ylidene-.beta.-ketocarboxylic acid ester, with a .beta.-ketocarboxylic acid ester and an amine or salt thereof, or with an enamino carboxylic acid ester or (B) through condensation of an aldehyde, an enamino carboxylic acid ester and a .beta.-ketocarboxylic acid ester. The said products have utility as cardiovascular agents.

REFERENCES:
patent: 3773773 (1973-11-01), Bossert

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