Pyranyl quinoline calcium channel blockers

Details Pyranyl quinoline calcium channel blockers Pyranyl quinoline calcium channel blockers

1989-12-19

1991-12-03

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514291, 540524, 546 89, 546 15, 544238, 544361, C07D491052, A61K 3144, A61K 3147

Patent

active

050700880

ABSTRACT:
Novel calcium channel blockers having the formula ##STR1## wherein X is oxygen or sulfur and wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 are as defined herein, are disclosed. These compounds are useful, for example, as anti-ischemic agents.

REFERENCES:
patent: 4086349 (1978-04-01), Morinaka et al.
V. A. Ashwood et al., "Synthesis and Antihypertensive Activity of 4-(Cyclic Amido)--2H--1-Benzopyrans", J. Med. Chem., 1986, 29, pp. 2194-2201.

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