Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1991-03-18
1991-12-03
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514107, 514118, 558 77, 558 84, 558155, 558157, 558159, 562 10, A61K 31665, A61K 3166, C07F 96574, C07F 924
Patent
active
050700820
ABSTRACT:
The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guadinine, isourea, isothiourea an biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phsophoric acid.
REFERENCES:
patent: 2394003 (1946-02-01), Newbery et al.
Lee Ving J.
Murdock Keith C.
Ambrose Michael G.
American Cyanamid Company
Lee Mary C.
Szatkowski T. S.
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