Formation of peptide bonds in the presence of isonitriles

Details Formation of peptide bonds in the presence of isonitriles Formation of peptide bonds in the presence of isonitriles

1974-12-09

1976-01-20

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

039337839

ABSTRACT:
Amino acids having masked amino groups react with amino acids having masked carboxyl groups to form peptide derivatives in good yields if the reaction medium contains an isonitrile. Isonitriles also are effective in causing condensation of amino acids having masked amino groups with compounds having active hydroxyl groups to the corresponding amino acid esters. The yields of the first-mentioned reaction are enhanced if the reaction mixture additionally contains one of the compounds having active hydroxyl groups. Both the peptide derivatives and the amino acid esters of the compounds having active hydroxyl groups are useful for peptide synthesis.

REFERENCES:
patent: 3721662 (1973-03-01), Fujino et al.
Yasumoto et al.: Chem. Abstr., 68:60069t(1968).
Gokel et al.: "Isonitrile Chemistry," I. Ugi, ed., Academic Press, New York, 1971, pp. 20-22.

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