Compositions of oral nondissolvable matrixes for transmucosal ad

Details Compositions of oral nondissolvable matrixes for transmucosal ad Compositions of oral nondissolvable matrixes for transmucosal ad

1989-09-05

1994-02-22

Michl, Paul R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Food or edible as carrier for pharmaceutical

424441, 424435, 424434, 424484, A61K 968

Patent

active

052884988

ABSTRACT:
Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to manufacturing techniques that enable therapeutic agents to be incorporated into nondissolvable drug containment matrixes which are capable of releasing the drug within a patient's mouth. An appliance or holder is preferably attached to the drug containment matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods. The nondissolvable drug containment matrix may include permeation enhancers to increase the drug absorption by the mucosal tissues of the mouth. The matrix composition may also include pH buffering agents to modify the saliva pH thereby increasing the absorption of the drug through the mucosal tissues.

REFERENCES:
patent: 4551329 (1985-11-01), Harris et al.
patent: 4749575 (1988-06-01), Rotman
patent: 4764378 (1988-08-01), Keith et al.
patent: 4818539 (1989-04-01), Shaw et al.
patent: 4863737 (1989-09-01), Stanley et al.

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