Aziridinyl quinone antitumor agents

Details Aziridinyl quinone antitumor agents Aziridinyl quinone antitumor agents

1978-10-24

1980-11-11

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D29512

Patent

active

042332150

ABSTRACT:
The use of aziridinyl quinones as antitumor agents against transplanted tumors in mice is disclosed. A compound which has been found to be particularly effective is the compound 2,5-diaziridinyl-3,6-bis (carboethoxyamino)-1,4-benzoquinone. Treatment is described in connection with several transplanted mouse tumor test systems including various forms of leukemia, for example, as well as B16 melanoma, Lewis lung carcinoma, and the ependymoblastoma brain tumor system.

REFERENCES:
patent: 2802001 (1957-08-01), Marxer
Chou et al., J. Med. Chem. 19, p. 1302 (1976).

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