Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1991-09-18
1993-07-06
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
5142228, 5142352, 514 63, 514312, 514255, 514303, 514310, 514248, 514259, 536 41, 536173, 544 582, 544 62, 544128, 544363, 544333, 544284, 544406, 544235, 546 14, 546118, 546148, 546157, C07H 504, C07D215227, C07D295195, A61K 3147
Patent
active
052254020
ABSTRACT:
Novel carbostyril derivatives of the formula: ##STR1## wherein R.sup.1 is H, NO.sub.2, alkoxy, alkoxycarbonyl, alkyl, halogen, optionally substituted amino, OH, CN, COOH, alkanoyloxy, hydrazinocarbonyl; q is 1 to 3, and R is a group of the formula ##STR2## [wherein R.sup.2 is H, alkoxycarbonyl, optionally substituted phenoxycarbonyl, phenylalkenyl-CO-, optionally substituted phenylalkanoyl, alkanoyl, alkenyl-CO-, optionally substituted phenyl--SO.sub.2 --, --CONR.sup.8 R.sup.9, optionally substituted heterocyclic group--CO--, naphthyl--CO--, thienylalkanoyl, tricyclo[3.3.1.1]alkanoyl, ##STR3## (R.sup.13 is OH, optionally substituted alkoxy, --NR.sup.32 R.sup.33, --O--A--(E).sub.l --NR.sup.4 R.sup.5, --(B).sub.l 'NR.sup.6 R.sup.7, etc.), n is 1 or 2, m is 0 or 1 to 3, R.sup.3 is alkyl, R.sup.10 is --(CO).sub.l --NR.sup.11 R.sup.12 ], and the bond between 3- and 4-position of carbostyril nucleus is single or double bond, which have excellent vasopressin antagonistic activities and are useful as vasodilator, hypotensive agent, water diuretics, platelet agglutination inhibitor, and a vasopressin antagonistic composition containing the compound as the active ingredient.
REFERENCES:
patent: 4960883 (1990-10-01), Tanabe et al.
J. Med. Chem., 24(7), 777-782 (1981), "Opiate Receptor Interaction of Compounds Derived from or Structurally Related to Fentanyl".
Klein et al Arch. Pharm. 1974 307(5) 360-6 Chemical Abstracts, vol. 81, 1974 Abstract 77786r.
Lobbezoo, et al. J. Med. Chem. 1981 24 777-782.
Kondo Kazumi
Miyamoto Hisashi
Nakaya Kenji
Ogawa Hidenori
Tominaga Michiaki
Otsuka Pharmaceutical Co. Ltd.
Shah Mukund J.
Ward E. C.
LandOfFree
Carbostyril derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Carbostyril derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carbostyril derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1689670