Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1991-08-12
1993-07-06
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 18, 514114, 514412, 514423, A61K 3702, C07K 506
Patent
active
052254011
ABSTRACT:
Congestive heart failure is treated by administration of a selective inhibitor of neutral endopeptidase and an angiotensin converting enzyme inhibitor. Captopril, fosinopril sodium, enalapril maleate and lisinopril are the preferred angiotensin converting enzyme inhibitors and the mercapto compounds of the formula ##STR1## are the preferred selective inhibitors of neutral endopeptidase.
REFERENCES:
patent: 4722810 (1988-02-01), Delaney et al.
patent: 4749688 (1988-06-01), Haslanger et al.
patent: 4801609 (1989-01-01), Haslanger et al.
patent: 4818749 (1989-04-01), Gold et al.
patent: 4826816 (1989-05-01), Andrews et al.
patent: 4906615 (1990-03-01), Berger
Physicians' Desk Reference, 45 Edition, 1991, pp. 1513-1516 and 2141-2143.
Jour. Am. Soc. of Nephrology, 23rd Annual Meeting, Dec., 1990, Abstract 44P.
Margulies et al., "Neutral Endopeptidase . . . ", Kidney International, vol. 38 (1990), pp. 67-72.
Federation of American Societies for Experimental Biology, Apr. 1991, Abstract 3775.
Seymour et al., "Effects of Renal Perfusion Pressure . . . ", Amer. Physiological Society, 1987, F234-F238.
Deedwania, "Angiotension-Converting Enzyme . . . ", Arch. Intern. Med., vol. 150, 1990, 1798-1805.
Cavero et al., "Cardiorenal Actions Of Neural . . . ", Circulation, vol. 82, No. 1, Jul. 1990, pp. 196-201.
Cody, "Pharmacology of Angiotensin-Converting Enzyme . . . ", Amer. Jour. of Cardio., vol. 66, 7D-13D, Oct. 1990.
Cohn, "Mechanism In Heart Failure . . . ", Amer. Jour. of Cardiology, vol. 66, 2D-6D, Oct. 1990.
Gottlieb et al., "Renal Effects of Angiotensin . . . ", Amer. Jour. of Cardiology, vol. 66, 14D-21D, Oct. 1990.
Seymour et al., "Potentiation of Renal Effects . . . ", Hypertension, vol. 14, No. 1, pp. 87-97, 1989.
Davis Stephen B.
E. R. Squibb & Sons Inc.
Lee Lester L.
LandOfFree
Treatment of congestive heart failure does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment of congestive heart failure, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of congestive heart failure will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1689658